| pos. | Title | Gross | |
|---|---|---|---|
| 1 |  | The Twilight Saga: New Moon (2009) | $280,962,758 |
| 2 |  | Avatar (2009) | $212,711,184 |
| 3 |  | The Hangover (2009) | $188,292,312 |
| 4 |  | The Blind Side (2010) | $184,195,981 |
| 5 |  | 2012 (2009) | $161,490,680 |
| 6 |  | G.I. Joe: The Rise of Cobra (2009) | $148,530,107 |
| 7 |  | Up (2009) | $143,772,310 |
| 8 |  | Gran Torino (2008) | $138,742,922 |
| 9 |  | Paul Blart Mall Cop (2009) | $137,179,873 |
| 10 |  | A Christmas Carol (2009) | $135,888,543 |
| 11 |  | X-Men Origins: Wolverine (2009) | $134,459,644 |
| 12 |  | Taken (2008) | $129,634,334 |
| 13 |  | G Force (2009) | $118,703,603 |
| 14 |  | Inglourious Basterds (2009) | $118,197,686 |
| 15 |  | District 9 (2009) | $114,694,911 |
| 16 |  | Slumdog Millionaire (2008) | $112,013,127 |
| 17 |  | Star Trek (2009) | $109,181,100 |
| 18 |  | Harry Potter and the Half Blood Prince (2009) | $109,117,107 |
| 19 |  | Watchmen (2009) | $103,478,414 |
| 20 |  | Cloudy With a Chance of Meatballs (2009) | $95,316,947 |