| pos. | Title | Gross | |
|---|---|---|---|
| 1 |  | Ghost (1990) | $185,822,408 |
| 2 |  | Pretty Woman (1990) | $150,612,200 |
| 3 |  | Teenage Mutant Ninja Turtles (1990) | $126,031,069 |
| 4 |  | Total Recall (1990) | $117,504,542 |
| 5 |  | Die Hard 2: Die Harder (1990) | $111,051,378 |
| 6 |  | Dick Tracy (1990) | $101,117,485 |
| 7 |  | Home Alone (1990) | $99,307,437 |
| 8 |  | Back to the Future Part III (1990) | $82,990,725 |
| 9 |  | Days of Thunder (1990) | $76,949,155 |
| 10 |  | Presumed Innocent (1990) | $76,827,346 |
| 11 |  | The Hunt For Red October (1990) | $74,723,730 |
| 12 |  | Another 48 Hrs () | $74,260,271 |
| 13 |  | Bird On a Wire (1990) | $63,896,510 |
| 14 |  | Flatliners (1990) | $50,891,643 |
| 15 |  | Problem Child (1991) | $45,866,990 |
| 16 |  | Arachnophobia (1991) | $45,053,945 |
| 17 |  | Robocop 2 (1990) | $40,708,868 |
| 18 |  | Marked For Death (1990) | $40,228,288 |
| 19 |  | Driving Miss Daisy (1990) | $39,516,055 |
| 20 |  | Dances With Wolves (1990) | $38,377,730 |