| pos. | Title | Gross | |
|---|---|---|---|
| 1 |  | Pirates of the Caribbean: Dead Man's Chest (2006) | £51,735,498 |
| 2 |  | Casino Royale (2006) | £49,641,433 |
| 3 |  | The Da Vinci Code (2006) | £30,249,489 |
| 4 |  | Ice Age: The Meltdown (2006) | £29,410,540 |
| 5 |  | Borat: Cultural Learnings of America For Make Benefit Glorious Nation of Kazakhstan (2006) | £23,863,341 |
| 6 |  | X-Men: The Last Stand (2006) | £19,066,987 |
| 7 |  | Cars (2006) | £16,099,943 |
| 8 |  | Superman Returns (2006) | £15,727,425 |
| 9 |  | Mission:Impossible III (2006) | £15,342,575 |
| 10 |  | Happy Feet (2006) | £13,862,684 |
| 11 |  | The Devil Wears Prada (2006) | £13,681,185 |
| 12 |  | Chicken Little (2005) | £13,293,986 |
| 13 |  | The Departed (2006) | £12,576,260 |
| 14 |  | Over the Hedge (2006) | £12,086,727 |
| 15 |  | The Chronicles of Narnia: The Lion the Witch and the Wardrobe (2005) | £10,682,209 |
| 16 |  | The Holiday (2006) | £10,226,830 |
| 17 |  | The Break Up (2006) | £10,049,790 |
| 18 |  | Walk the Line (2006) | £9,737,493 |
| 19 |  | Brokeback Mountain (2006) | £9,469,032 |
| 20 |  | Big Mommas House 2 (2006) | £9,078,398 |