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The superhero re-release pulled in $60 million from overseas markets alongside its $26 million domestic take, raising its historic lifetime total to $2.885 billion.
The sudden Marvel wave knocked Zach Cregger's Resident Evil~2026 reboot down to the number two spot globally after its week at the top.
The horror film brought in $50.3 million worldwide for its second frame, driving its cumulative global box office total to a lucrative $196.4 million.
Highest new movie this weekend
Avengers: Endgame opened strongly, going straight to number one in its first weekend. The Encore version of the 2019 movie which extra scenes linking it to Avengers Doomsday has little competition to reach the top.
As for last week's number one film, Resident Evil, the ride at the absolute top has come to an end. It slipped down the ladder to number 2 this weekend, though its accounting team won't mind too much given its total gross now sits at £8,629,328.
Highest new movie this weekend
There is a new winner at the top of the chart for the weekend of 18th - 20th September 2026, with Resident Evil~2026 securing the number one spot during its opening weekend.
The change at the top means last week's leader, Practical Magic 2, has taken a step back to number 2. However, it continues to enjoy a highly successful theater run, accumulating a strong overall gross of £5,570,029 to date.
Highest new movie this weekend
After five weeks at the top of the global box office, Spider-Man: Brand New Day has surrendered the number one spot to The Odyssey. Reclaiming the crown, The Odyssey has now grossed well over $1.5 billion since its release.
Meanwhile, the weekend's highest-grossing debut came from Mirzapur, entering the charts at number five.
Highest new movie this weekend
Spider-Man: Brand New Day has officially made box office history, shattering records with a stunning $360 million domestic debut to claim the number one spot at the North American box office.
The highly anticipated Marvel blockbuster officially dethroned
Avengers: Endgame (2019) to secure the biggest opening weekend of all time.
Meanwhile, Christopher Nolan's The Odyssey slipped to the number two spot but maintained incredible momentum, pulling in a strong $51 million in its sophomore weekend.
Highest new movie this weekend